Inhibition of mitochondrial permeability transition pore opening: the holy grail of cardioprotection

被引：250

作者：

Heusch, Gerd ^{[1
]}

Boengler, Kerstin ^{[1
]}

Schulz, Rainer ^{[1
]}

机构：

[1] Univ Essen Gesamthsch, Sch Med, Inst Pathophysiol, D-45122 Essen, Germany

来源：

BASIC RESEARCH IN CARDIOLOGY | 2010年 / 105卷 / 02期

关键词：

GLYCOGEN-SYNTHASE KINASE-3-BETA; REPERFUSION INJURY; CELL-DEATH; CYCLOPHILIN-D; ISCHEMIA-REPERFUSION; CYCLOSPORINE-A; DISEASE; MYOCARDIUM; MECHANISMS; PROTECTION;

D O I：

10.1007/s00395-009-0080-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：151 / 154

页数：4

共 44 条

[1] Postconditioning inhibits mitochondrial permeability transition [J].

Argaud, L ;

Gateau-Roesch, O ;

Raisky, O ;

Loufouat, J ;

Robert, D ;

Ovize, M .

CIRCULATION, 2005, 111 (02) :194-197

[2] Increased mitochondrial calcium coexists with decreased reperfusion injury in postconditioned (but not preconditioned) hearts [J].

Argaud, Laurent ;

Gateau-Roesch, Odile ;

Augeul, Lionel ;

Couture-Lepetit, Elisabeth ;

Loufouat, Joseph ;

Gomez, Ludovic ;

Robert, Dominique ;

Ovize, Michel .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2008, 294 (01) :H386-H391

[3] Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death [J].

Baines, Christopher P. ;

Kaiser, Robert A. ;

Sheiko, Tatiana ;

Craigen, William J. ;

Molkentin, Jeffery D. .

NATURE CELL BIOLOGY, 2007, 9 (05) :550-U122

[4] The mitochondrial permeability transition pore and ischemia-reperfusion injury [J].

Baines, Christopher P. .

BASIC RESEARCH IN CARDIOLOGY, 2009, 104 (02) :181-188

[5] Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death [J].

Baines, CP ;

Kaiser, RA ;

Purcell, NH ;

Blair, NS ;

Osinska, H ;

Hambleton, MA ;

Brunskill, EW ;

Sayen, MR ;

Gottlieb, RA ;

Dorn, GW ;

Robbins, J ;

Molkentin, JD .

NATURE, 2005, 434 (7033) :658-662

[6] Properties of the permeability transition pore in mitochondria devoid of cyclophilin D [J].

Basso, E ;

Fante, L ;

Fowlkes, J ;

Petronilli, V ;

Forte, MA ;

Bernardi, P .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (19) :18558-18561

[7] Phosphate is essential for inhibition of the mitochondrial permeability transition pore by cyclosporin A and by cyclophilin D ablation [J].

Basso, Emy ;

Petronilli, Valeria ;

Forte, Michael A. ;

Bernardi, Paolo .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (39) :26307-26311

[8] The mitochondrial permeability transition from in vitro artifact to disease target [J].

Bernardi, P ;

Krauskopf, A ;

Basso, E ;

Petronilli, V ;

Blalchy-Dyson, E ;

Di Lisa, F ;

Forte, MA .

FEBS JOURNAL, 2006, 273 (10) :2077-2099

[9] Mitochondrial respiration and membrane potential after low-flow ischemia are not affected by ischemic preconditioning [J].

Boengler, Kerstin ;

Gres, Petra ;

Dodoni, Giuliano ;

Konietzka, Ina ;

Di Lisa, Fabio ;

Heusch, Gerd ;

Schulz, Rainer .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2007, 43 (05) :610-615

[10] Presence of connexin 43 in subsarcolemmal, but not in interfibrillar cardiomyocyte mitochondria [J].

Boengler, Kerstin ;

Stahlhofen, Sabine ;

van de Sand, Anita ;

Gres, Petra ;

Ruiz-Meana, Marisol ;

Garcia-Dorado, David ;

Heusch, Gerd ;

Schulz, Rainer .

BASIC RESEARCH IN CARDIOLOGY, 2009, 104 (02) :141-147

← 1 2 3 4 5 →