Connective tissue growth factor in retrocorneal membranes and corneal scars

被引：31

作者：

Wunderlich, K

Senn, BC

Reiser, P

Pech, M

Flammer, J

Meyer, P ^{[1
]}

机构：

[1] Univ Basel, Univ Eye Clin, Dept Ophthalmol, CH-4000 Basel, Switzerland

[2] Univ Basel, Inst Pathol, Dept Ophthalmol, CH-4000 Basel, Switzerland

[3] F Hoffmann La Roche & Co Ltd, CH-4002 Basel, Switzerland

来源：

OPHTHALMOLOGICA | 2000年 / 214卷 / 05期

关键词：

cornea; connective tissue growth factor; growth factors; retrocorneal membranes;

D O I：

10.1159/000027517

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

We studied the localization and distribution of connective tissue growth factor (CTGF) in corneal scar tissue and membranes using in situ hybridization in 8 corneas from keratoplasty and 4 normal corneas. Identification of the cells was done with immunohistochemistry for SM-alpha-actin, vimentin, and Lu5. CTGF mRNA was found in activated corneal fibroblasts in 7 of 8 scars, 7 of 8 retrocorneal membranes and 2 subepithelial membranes, whereas the control corneas showed no CTGF mRNA expression. Vimentin was positive in all scars, retrocorneal and subepithelial membranes, SM-alpha-actin in 7 of 8 scars and 6 of 8 retrocorneal membranes, These results suggest that CTGF plays a crucial role in corneal wound healing and membrane formation, copyright (C) 2000 S. Karger AG, Basel.

引用

页码：341 / 346

页数：6

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FABRICANT RN, 1981, ARCH OPHTHALMOL-CHIC, V99, P305

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