Analysis of the centromeric regions of the human genome assembly

被引:137
作者
Rudd, MK [1 ]
Willard, HF [1 ]
机构
[1] Duke Univ, Inst Genome Sci & Policy, Durham, NC 27710 USA
关键词
D O I
10.1016/j.tig.2004.08.008
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The sequence of the human genome is not yet complete, and major gaps remain at the centromere region of each chromosome, which is comprised of repetitive alpha satellite DNA. In this article, we describe the sequences in the vicinity of the centromere that are included in the current genome assembly, analyze the similar to7 Mb of satellite that have been assembled thus far and anticipate the nature of the sequences that remain to be accounted for.
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页码:529 / 533
页数:5
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