Lung development and implications for hypoplasia found in congenital diaphragmatic hernia

被引:23
作者
Kinane, T. Bernard [1 ]
机构
[1] Massachusetts Gen Hosp, Boston, MA 02114 USA
关键词
congenital diaphragmatic hernia (CDH); pulmonary hypoplasia; branching; lung development;
D O I
10.1002/ajmg.c.30124
中图分类号
Q3 [遗传学];
学科分类号
071007 [遗传学]; 090102 [作物遗传育种];
摘要
Congenital diaphragmatic hernia (CDH) is associated with various degrees of pulmonary hypoplasia and severe persistent pulmonary hypertension in the newborn. These conditions have significant implications for the outcome for the patient. Defects in early lung development are likely to be central to the generation of hypoplasia. A number of mouse models with defects in pathways that are central to lung development were found to have CDH. Understanding all aspects of early lung development will provide fresh insight into the pathogenesis of CDH and its associated conditions. (C) 2007 Wiley-Liss, Inc.
引用
收藏
页码:117 / 124
页数:8
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