Role of Cbfa1 in osteoblast differentiation and function

被引：145

作者：

Karsenty, G ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2000年 / 11卷 / 05期

关键词：

Cbfa1; differentiation; function; osteoblast;

D O I：

10.1006/scdb.2000.0188

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Among the multiple cell lineages whose differentiation is affected by a runt-related gene the osteoblast is a relative newcomer. Molecular biology, developmental biology and mouse and human genetic studies have demonstrated that Cbfa1 is a critical regulator of osteoblast differentiation in vertebrates. Cbfa1 is not only a differentiation factor but also a regulator of bone formation by differentiated osteoblasts beyond development. Thus, Cbfa1 controls osteogenesis at multiple stages.

引用

页码：343 / 346

页数：4

共 24 条

[1] Dissociation between bone resorption and bone formation in osteopenic transgenic mice
Corral, DA
Amling, M
Priemel, M
Loyer, E
Fuchs, S
Ducy, P
Baron, R
Karsenty, G
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (23) : 13835 - 13840
[2] D'Souza RN, 1999, DEVELOPMENT, V126, P2911
[3] DUCY P, 1995, MOL CELL BIOL, V15, P1858
[4] Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
Ducy, P
Zhang, R
Geoffroy, V
Ridall, AL
Karsenty, G
[J]. CELL, 1997, 89 (05) : 747 - 754
[5] A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development
Ducy, P
Starbuck, M
Priemel, M
Shen, JH
Pinero, G
Geoffroy, V
Amling, M
Karsenty, G
[J]. GENES & DEVELOPMENT, 1999, 13 (08) : 1025 - 1036
[6] Genomic organization, expression of the human CBFA1 gene, and evidence for an alternative splicing event affecting protein function
Geoffroy, V
Corral, DA
Zhou, L
Lee, B
Karsenty, G
[J]. MAMMALIAN GENOME, 1998, 9 (01) : 54 - 57
[7] THE LOCALIZED REQUIREMENTS FOR A GENE AFFECTING SEGMENTATION IN DROSOPHILA - ANALYSIS OF LARVAE MOSAIC FOR RUNT
GERGEN, JP
WIESCHAUS, EF
[J]. DEVELOPMENTAL BIOLOGY, 1985, 109 (02) : 321 - 335
[8] OSTEOCALCIN AND MATRIX GLA PROTEIN - VITAMIN K-DEPENDENT PROTEINS IN BONE
HAUSCHKA, PV
LIAN, JB
COLE, DEC
GUNDBERG, CM
[J]. PHYSIOLOGICAL REVIEWS, 1989, 69 (03) : 990 - 1047
[9] Bone morphogenetic proteins: Multifunctional regulators of vertebrate development
Hogan, BLM
[J]. GENES & DEVELOPMENT, 1996, 10 (13) : 1580 - 1594
[10] Inada M, 1999, DEV DYNAM, V214, P279, DOI 10.1002/(SICI)1097-0177(199904)214:4<279::AID-AJA1>3.0.CO

← 1 2 3 →