Chromatin dynamics and the preservation of genetic information

被引：232

作者：

Downs, Jessica A. ^{[1
]}

Nussenzweig, Michel C.

Nussenzweig, Andre

机构：

[1] Univ Sussex, MRC, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England

[2] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10021 USA

[3] NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA

来源：

NATURE | 2007年 / 447卷 / 7147期

关键词：

D O I：

10.1038/nature05980

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The integrity of the genome is frequently challenged by double-strand breaks in the DNA. Defects in the cellular response to double-strand breaks are a major cause of cancer and other age-related pathologies; therefore, much effort has been directed at understanding the enzymatic mechanisms involved in recognizing, signalling and repairing double-strand breaks. Recent work indicates that chromatin - the fibres into which DNA is packaged with a proteinaceous structural polymer - has an important role in initiating, propagating and terminating this cellular response to DNA damage.

引用

页码：951 / 958

页数：8

共 99 条

[1] H2B (Ser10) phosphorylation is induced during apoptosis and meiosis in S-cerevisiae
Ahn, SH
Henderson, KA
Keeney, S
Allis, CD
[J]. CELL CYCLE, 2005, 4 (06) : 780 - 783
[2] Sterile 20 kinase phosphorylates histone H2B at serine 10 during hydrogen peroxide-induced apoptosis in S. cerevisiae
Ahn, SH
Cheung, WL
Hsu, JY
Diaz, RL
Smith, MM
Allis, CD
[J]. CELL, 2005, 120 (01) : 25 - 36
[3] A Rsc3/Rsc30 zinc cluster dimer reveals novel roles for the chromatin remodeler RSC in gene expression and cell cycle control
Angus-Hill, ML
Schlichter, A
Roberts, D
Erdjument-Bromage, H
Tempst, P
Cairns, BR
[J]. MOLECULAR CELL, 2001, 7 (04) : 741 - 751
[4] DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
Bakkenist, CJ
Kastan, MB
[J]. NATURE, 2003, 421 (6922) : 499 - 506
[5] Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks
Bekker-Jensen, S
Lukas, C
Kitagawa, R
Melander, F
Kastan, MB
Bartek, J
Lukas, J
[J]. JOURNAL OF CELL BIOLOGY, 2006, 173 (02) : 195 - 206
[6] Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1
Bekker-Jensen, S
Lukas, C
Melander, F
Bartek, J
Lukas, J
[J]. JOURNAL OF CELL BIOLOGY, 2005, 170 (02) : 201 - 211
[7] Genes required for ionizing radiation resistance in yeast
Bennett, CB
Lewis, LK
Karthikeyan, G
Lobachev, KS
Jin, YH
Sterling, JF
Snipe, JR
Resnick, MA
[J]. NATURE GENETICS, 2001, 29 (04) : 426 - 434
[8] Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair
Bird, AW
Yu, DY
Pray-Grant, MG
Qiu, QF
Harmon, KE
Megee, PC
Grant, PA
Smith, MM
Christman, MF
[J]. NATURE, 2002, 419 (6905) : 411 - 415
[9] Increased tumorigenicity and sensitivity to ionizing radiation upon loss of chromosomal protein HMGN1
Birger, Y
Catez, F
Furusawa, T
Lim, JH
Prymakowska-Bosak, M
West, KL
Postnikov, YV
Haines, DC
Bustin, M
[J]. CANCER RESEARCH, 2005, 65 (15) : 6711 - 6718
[10] Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair
Botuyan, Maria Victoria
Lee, Joseph
Ward, Irene M.
Kim, Ja-Eun
Thompson, James R.
Chen, Junjie
Mer, Georges
[J]. CELL, 2006, 127 (07) : 1361 - 1373

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