The mGlu2/3 receptor agonist LY379268 selectively blocks amphetamine ambulations and rearing

被引：81

作者：

Cartmell, J ^{[1
]}

Monn, JA ^{[1
]}

Schoepp, DD ^{[1
]}

机构：

[1] Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Neurosci Res, Indianapolis, IN 46285 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2000年 / 400卷 / 2-3期

关键词：

glutamate receptor; metabotropic; amphetamine; LY379268; motor activity; stereotypy;

D O I：

10.1016/S0014-2999(00)00423-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have previously reported that the specific group II metabotropic glutamate receptor agonist LY379268 inhibited phencyclidine (PCP)-induced motor activations in rats, but had mixed effects on behaviors produced by amphetamine. Here, LY379268 (1 mg/kg subcutaneous (s.c.)) attenuated amphetamine-induced ambulations and rearing but did not alter amphetamine-evoked fine motor movements. Consistent with a mechanism involving mGlu(2/3) receptors, the inhibitory actions of LY379268 on ambulations and rearing were reversed by LY341495, a mGlu(2/3) receptor antagonist. These data further suggest antipsychotic actions of mGlu(2/3) receptor agonists with a low propensity for extra-pyramidal side effects. (C) 2000 Published by Elsevier Science B.V.

引用

页码：221 / 224

页数：4

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