Omeprazole inhibits IL-4 and IL-13 signaling signal transducer and activator of transcription 6 activation and reduces lung inflammation in murine asthma

被引:46
作者
Cortes, Jose R. [1 ]
Rivas, Maria D. [1 ]
Molina-Infante, Javier [2 ]
Gonzalez-Nunez, Maria A. [3 ]
Perez-G, Moises [1 ]
Masa, Juan F. [4 ]
Sanchez, Juan F. [5 ]
Zamorano, Jose [1 ]
机构
[1] Hosp San Pedro de Alcantara, Unidad Invest, Caceres, Spain
[2] Hosp San Pedro de Alcantara, Serv Digest, Caceres, Spain
[3] Hosp San Pedro de Alcantara, Serv Anat Patol, Caceres, Spain
[4] Hosp San Pedro de Alcantara, Serv Neumol, Ctr Invest Biomed Red Enfermedades Resp CiberRes, Caceres, Spain
[5] Hosp San Pedro de Alcantara, Med Interna Serv, Caceres, Spain
关键词
EFFICACY;
D O I
10.1016/j.jaci.2009.06.023
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:607 / 610
页数:5
相关论文
共 9 条
[1]   Sites of reaction of the gastric H,K-ATPase with extracytoplasmic thiol reagents [J].
Besancon, M ;
Simon, A ;
Sachs, G ;
Shin, JM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (36) :22438-22446
[2]   Treatment of Eosinophilic Esophagitis: Overview, Current Limitations, and Future Direction [J].
Bohm, Matthew ;
Richter, Joel E. .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2008, 103 (10) :2635-2644
[3]   Efficacy of soluble IL-4 receptor for the treatment of adults with asthma [J].
Borish, LC ;
Nelson, HS ;
Corren, J ;
Bensch, G ;
Busse, WW ;
Whitmore, JB ;
Agosti, JM .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 107 (06) :963-970
[4]  
Hanania NA, 2009, NEW ENGL J MED, V360, P1487, DOI 10.1056/NEJMoa0806290
[5]   Endogenous airway acidification - Implications for asthma pathophysiology [J].
Hunt, JF ;
Fang, KZ ;
Malik, R ;
Snyder, A ;
Malhotra, N ;
Platts-Mills, TAE ;
Gaston, B .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 161 (03) :694-699
[6]  
IM WB, 1985, J BIOL CHEM, V260, P9452
[7]   Intratracheal IL-13 induces eosinophilic esophagitis by an IL-5, eotaxin-1, and STAT6-dependent mechanism [J].
Mishra, A ;
Rothenberg, ME .
GASTROENTEROLOGY, 2003, 125 (05) :1419-1427
[8]   Treatment of cells with n-alpha-tosyl-L-phenylalanine-chloromethyl ketone induces the proteolytic loss of STAT6 transcription factor [J].
Perez-G, Moises ;
Cortes, Jose R. ;
Rivas, Maria D. ;
Masa, F. ;
Zamorano, Jose .
MOLECULAR IMMUNOLOGY, 2008, 45 (15) :3896-3901
[9]   Effect of omeprazole and domperidone on adult astmatics with gastroesophageal reflux [J].
Sharma, Bhavneesh ;
Sharma, Manisha ;
Daga, Mradul Kumar ;
Sachdev, Gopal Krishan ;
Bondi, Elliott .
WORLD JOURNAL OF GASTROENTEROLOGY, 2007, 13 (11) :1706-1710