Antiprogestins mediate differential effects on glucocorticoid receptor remodeling of chromatin structure

被引:20
作者
Fryer, CJ
Nordeen, SK
Archer, TK
机构
[1] Univ Western Ontario, London Reg Canc Ctr, Dept Obstet Gynecol, London, ON N6A 4L6, Canada
[2] Univ Western Ontario, London Reg Canc Ctr, Dept Biochem & Oncol, London, ON N6A 4L6, Canada
[3] Univ Colorado, Hlth Sci Ctr, Dept Pathol, Denver, CO 80262 USA
关键词
D O I
10.1074/jbc.273.2.1175
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We examined the mechanism(s) by which the progesterone receptor (PR) is able to inhibit glucocorticoid receptor (GR) activation from the mouse mammary tumor virus (MMTV) promoter in vivo. Using specific hormone antagonists, we demonstrate that the PR complexed with an type II antiprogestin blocks glucocorticold-induced activation of the MMTV promoter, However, when complexed with a type I antiprogestin the PR is unable to block glucocorticoid-induced activation. PR repression of GrR activity results from the inhibition of the ability of the GR to remodel chromatin such that the antiprogestin-occupied/PR prevents the glucocorticold induced assembly of a preinitiation complex at MMTV promoter. These experiments suggest that the specific chromatin organization of the MMTV promoter provides a mechanism for regulating cross-talk between the GR and PR in vivo.
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页码:1175 / 1183
页数:9
相关论文
共 68 条
[1]   Induction of a novel conformation in the progesterone receptor by ZK299 involves a defined region of the carboxyl-terminal tail [J].
Allan, GF ;
Lombardi, E ;
HaynesJohnson, D ;
Palmer, S ;
Kiddoe, M ;
Kraft, P ;
Campen, C ;
Rybczynski, P ;
Combs, DW ;
Phillips, A .
MOLECULAR ENDOCRINOLOGY, 1996, 10 (10) :1206-1213
[2]   THE ORIGIN OF NUCLEAR RECEPTOR PROTEINS - A SINGLE PRECURSOR DISTINCT FROM OTHER TRANSCRIPTION FACTORS [J].
AMERO, SA ;
KRETSINGER, RH ;
MONCRIEF, ND ;
YAMAMOTO, KR ;
PEARSON, WR .
MOLECULAR ENDOCRINOLOGY, 1992, 6 (01) :3-7
[3]   DIFFERENTIAL STEROID-HORMONE INDUCTION OF TRANSCRIPTION FROM THE MOUSE MAMMARY-TUMOR VIRUS PROMOTER [J].
ARCHER, TK ;
LEE, HL ;
CORDINGLEY, MG ;
MYMRYK, JS ;
FRAGOSO, G ;
BERARD, DS ;
HAGER, GL .
MOLECULAR ENDOCRINOLOGY, 1994, 8 (05) :568-576
[4]   THE DIFFERENTIAL CAPACITY OF GLUCOCORTICOIDS AND PROGESTINS TO ALTER CHROMATIN STRUCTURE AND INDUCE GENE-EXPRESSION IN HUMAN BREAST-CANCER CELLS [J].
ARCHER, TK ;
ZANIEWSKI, E ;
MOYER, ML ;
NORDEEN, SK .
MOLECULAR ENDOCRINOLOGY, 1994, 8 (09) :1154-1162
[5]   TRANSCRIPTION FACTOR ACCESS IS MEDIATED BY ACCURATELY POSITIONED NUCLEOSOMES ON THE MOUSE MAMMARY-TUMOR VIRUS PROMOTER [J].
ARCHER, TK ;
CORDINGLEY, MG ;
WOLFORD, RG ;
HAGER, GL .
MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (02) :688-698
[6]   TRANSCRIPTION FACTOR LOADING ON THE MMTV PROMOTER - A BIMODAL MECHANISM FOR PROMOTER ACTIVATION [J].
ARCHER, TK ;
LEFEBVRE, P ;
WOLFORD, RG ;
HAGER, GL .
SCIENCE, 1992, 255 (5051) :1573-1576
[7]  
ARCHER TK, 1995, NUCLEOSOME, P123
[8]  
ARCHER TK, 1989, STEROID THYROID HORM, P221
[9]   ENHANCEMENT OF HUMAN ESTROGEN-RECEPTOR ACTIVITY BY SPT6 - A POTENTIAL COACTIVATOR [J].
BANIAHMAD, C ;
NAWAZ, Z ;
BANIAHMAD, A ;
GLEESON, MAG ;
TSAI, MJ ;
OMALLEY, BW .
MOLECULAR ENDOCRINOLOGY, 1995, 9 (01) :34-43
[10]  
BEATO M, 1995, ONCOGENESIS, V2, P1991