Diheteropeptin, a new substance with TGF-β like activity, produced by a fungus, Diheterospora chlamydosporia I.: Production, isolation and biological activities

被引：17

作者：

Masuoka, Y ^{[1
]}

Shin-Ya, K

Kim, YB

Yoshida, M

Nagai, K

Suzuki, K

Hayakawa, Y

Seto, H

机构：

[1] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan

[2] Univ Tokyo, Grad Sch Agr & Life Sci, Bunkyo Ku, Tokyo 1138657, Japan

[3] Yamanouchi Pharmaceut Co Ltd, Microbiol Labs, Inst Drug Discovery Res, Itabashi Ku, Tokyo 1748511, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2000年 / 53卷 / 08期

关键词：

D O I：

10.7164/antibiotics.53.788

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new metabolite, diheteropeptin, was found in the culture broth of Diheterospora chlamydosporia Q58044 by screening for TGF-beta-like active substances. Diheteropeptin was extracted from the culture supernatant and purified by a series of chromatographies such as silica gel, gel filtration and HPLC. Diheteropeptin exhibited cytostatic activity in Mv1Lu cells with an IC50 value of 20.3 mu M and inhibited histone deacetylase.

引用

页码：788 / 792

页数：5

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