Diclofenac-enriched artificial sediment induces oxidative stress in Hyalella azteca

被引：63

作者：

Carolina Oviedo-Gomez, Dennis Gloria ^{[1
]}

Galar-Martinez, Marcela ^{[2
]}

Garcia-Medina, Sandra ^{[2
]}

Razo-Estrada, Celene ^{[2
]}

Manuel Gomez-Olivan, Leobardo ^{[1
]}

机构：

[1] Univ Autonoma Estado Mexico, Dept Farm, Fac Quim, Toxicol Lab, Toluca 50120, Estado Mexico, Mexico

[2] Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Secc Grad & Invest, Lab Toxicol Acuat, Mexico City 11340, DF, Mexico

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2010年 / 29卷 / 01期

关键词：

Diclofenac; Artificial sediment; Oxidative stress; Hyalella azteca; PHARMACEUTICAL DRUG DICLOFENAC; ENVIRONMENTAL RISK-ASSESSMENT; SUPEROXIDE-DISMUTASE; AQUATIC ENVIRONMENT; LIPID-PEROXIDATION; SURFACE WATERS; BIOMARKERS; TOXICITY; PHOTODEGRADATION; CARBAMAZEPINE;

D O I：

10.1016/j.etap.2009.09.004

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Diclofenac is a nonsteroidal anti-inflammatory drug widely used in Mexico where it is sold over the counter. It enters water bodies through municipal and industrial discharges, posing a risk to water systems and aquatic organisms. Diclofenac-enriched artificial sediment was used to evaluate the toxicity of this pharmaceutical on the sentinel species Hyalella azteca, using oxidative stress biomarkers in order to determine if the set of tests used in this study is a suitable early damage biomarker. The median lethal concentration (72-h LC50) was determined and oxidative stress was evaluated using lipid peroxidation, protein carbonyl content to evaluate oxidized protein content, and the activity of superoxide dismutase, catalase, and glutathione peroxidase. All biomarkers were significantly altered. Diclofenac induces oxidative stress in H. azteca and the set of tests used (lipid peroxidation, protein carbonyl content, antioxidant enzyme activities) constitutes an adequate early damage biomarker for evaluating the toxicity of this pharmaceutical group in aquatic species. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：39 / 43

页数：5

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