2-Year Results of the AUTAX (Austrian Multivessel TAXUS-Stent) Registry Beyond the SYNTAX (Synergy Between Percutaneous Coronary Intervention With TAXUS and Cardiac Surgery) Study

被引：12

作者：

Gyoengyoesi, Mariann ^{[1
]}

Christ, Guenter ^{[1
]}

Lang, Irene ^{[1
]}

Kreiner, Gerhard ^{[1
]}

Sochor, Heinz ^{[1
]}

Probst, Peter ^{[1
]}

Neunteufl, Thomas ^{[1
]}

Badr-Eslam, Rosa ^{[1
]}

Winkler, Susanne ^{[1
]}

Nyolczas, Noemi ^{[1
]}

Posa, Aniko ^{[1
]}

Leisch, Franz ^{[2
]}

Karnik, Ronald ^{[3
]}

Siostrzonek, Peter ^{[4
]}

Harb, Stefan ^{[5
]}

Heigert, Matthias ^{[6
]}

Zenker, Gerald ^{[7
]}

Benzer, Werner ^{[8
]}

Bonner, Gerhard ^{[9
]}

Kaider, Alexandra ^{[10
]}

Glogar, Dietmar ^{[1
]}

机构：

[1] Med Univ Vienna, Dept Cardiol, Vienna, Austria

[2] Allgemeines Krankenhaus Stadt Linz, Linz, Austria

[3] Rudolfstiftung Vienna, Vienna, Austria

[4] Krankenhaus Barmherzigen Schwestern, Linz, Austria

[5] Landeskrankenhaus Graz W, Graz, Austria

[6] St Johannes Spital, Salzburg, Austria

[7] Landeskrankenhaus, Bruck An Der Mur, Austria

[8] Acad Hosp, Dept Intervent Cardiol, Feldkirch, Austria

[9] Confraternitat Privatklin Josefstadt, Vienna, Austria

[10] Med Univ Vienna, Sect Clin Biometr, Core Unit Med Stat & Informat, Vienna, Austria

来源：

JACC-CARDIOVASCULAR INTERVENTIONS | 2009年 / 2卷 / 08期

关键词：

revascularization; catheterization; stents; coronary disease; SYNTAX score; DRUG-ELUTING STENTS; ARTERY-BYPASS GRAFT; FOLLOW-UP; ON-PUMP; ANGIOPLASTY; IMPLANTATION; OUTCOMES; DISEASE; HEALTH; TRIALS;

D O I：

10.1016/j.jcin.2009.05.019

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives The multicenter AUTAX (Austrian Multivessel TAXUS-Stent) registry investigated the 2-year clinical/angiographic outcomes of patients with multivessel coronary artery disease after implantation of TAXUS Express stents (Boston Scientific, Natick, Massachusetts), in a "real-world" setting. Background The AUTAX registry included patients with 2- or 3-vessel disease, with/without previous percutaneous coronary intervention (PCI) and concomitant surgery. Methods Patients (n = 441, 64 +/- 12 years, 78% men) (n = 1,080 lesions) with possible complete revascularization by PCI were prospectively included. Median clinical follow-up was 753 (quartiles 728 to 775) days after PCI in 95.7%, with control angiography of 78% at 6 months. The primary end point was the composite of major adverse cardiac (nonfatal acute myocardial infarction [AMI], all-cause mortality, target lesion revascularization [TLR]) and cerebrovascular events (MACCE). Potential risk factor effects on 2-year MACCE were evaluated using Cox regression. Results Complete revascularization was successful in 90.5%, with left main PCI of 6.8%. Rates of acute, subacute, and late stent thrombosis were 0.7%, 0.5%, and 0.5%. Two-year follow-up identified AMI (1.4%), death (3.6%), stroke (0.2%), and TLR (13.1%), for a composite MACCE of 18.3%. The binary restenosis rate was 10.8%. The median of cumulative SYNTAX score was 23.0 (range 12.0 to 56.5). The SYNTAX score did not predict TLR or MACCE, due to lack of scoring of restenotic or bypass stenoses (29.8%). Age (hazard ratio [HR]: 1.03, p = 0.019) and acute coronary syndrome (HR: 2.1, p = 0.001) were significant predictors of 2-year MACCE. Incomplete revascularization predicted death or AMI (HR: 3.84, p = 0.002). Conclusions With the aim of complete revascularization, TAXUS stent implantations can be safe for patients with multivessel disease. The AUTAX registry including patients with post-PCI lesions provides additional information to the SYNTAX (Synergy Between Percutaneous Coronary Intervention With TAXUS and Cardiac Surgery) study. (Austrian Multivessel TAXUS-Stent Registry; NCT00738686) (J Am Coll Cardiol Intv 2009;2:718-27) (C) 2009 by the American College of Cardiology Foundation

引用

页码：718 / 727

页数：10

共 25 条

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