Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis

被引：238

作者：

Kisseleva, Tatiana ^{[1
]}

Brenner, David A. ^{[1
]}

机构：

[1] Columbia Univ, Coll Phys & Surg, Ctr Med, Dept Med, New York, NY 10032 USA

来源：

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2007年 / 22卷

关键词：

collagen type I; hepatic stellate cells; liver fibrosis;

D O I：

10.1111/j.1440-1746.2006.04658.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Liver fibrosis is caused by many chronic diseases. Liver injury results in activation of collagen-producing cells and excessive deposition of extracellular matrix proteins. This process is orchestrated by many cell types. Hepatocytes apoptosis and inflammatory cells trigger secretion of profibrogenic and proinflammatory cytokines, such as transforming growth factor-beta 1, angiotensin II, leptin, which in turn activates hepatic stellate cells, the major source of collagen type I. This review is focused on recent progress in the study of the pathogenesis of liver fibrosis.

引用

页码：S73 / S78

页数：6

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