The Epstein-Barr virus BARF1 gene encodes a novel, soluble colony-stimulating factor-1 receptor

被引：117

作者：

Strockbine, LD

Cohen, JI

Farrah, T

Lyman, SD

Wagener, F

DuBose, RF

Armitage, RJ

Spriggs, MK

机构：

[1] Immunex Res & Dev Corp, Mol Biol, Seattle, WA 98101 USA

[2] NIAID, Clin Invest Lab, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF VIROLOGY | 1998年 / 72卷 / 05期

关键词：

D O I：

10.1128/JVI.72.5.4015-4021.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Epstein-Barr virus (EBV) is a ubiquitous herpesvirus associated with infectious mononucleosis and several tumors. The BARF1 gene is transcribed early after EBV infection from the BamHI A fragment of the EBV genome. Evidence shown here indicates that the BARF1 protein is secreted into the medium of transfected cells and from EBV-carrying B cells induced to allow lytic replication of the virus. Expression cloning identified colony-stimulating factor-1 (CSF-1) as a ligand for BARF1, Computer-assisted analyses indicated that subtle amino acid sequence homology exists between BARF1 and c-fms, the cellular proto-oncogene that is the receptor for CSF-1. Recombinant BARF1 protein was found to be biologically active, and it neutralized the proliferative effects of human CSF-1 in a dose-dependent fashion when assayed in vitro. Since CSF-1 is a pleiotropic cytokine best known for its differentiating effects on macrophages, these data suggest that BARF1 may function to modulate the host immune response to EBV infection.

引用

页码：4015 / 4021

页数：7

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