mtDNA synthesis ignites the inflammasome

被引:9
作者
Bordon, Yvonne
机构
[1] Nature Reviews Immunology,
关键词
D O I
10.1038/s41577-018-0049-8
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
071005 [微生物学]; 100108 [医学免疫学];
摘要
Macrophage priming by inflammatory stimuli drives the new synthesis and oxidation of mitochondrial DNA, which is essential for NLRP3 inflammasome activation.
引用
收藏
页码:539 / 539
页数:1
相关论文
共 3 条
[1]
Zhong Z(2018)New mitochondrial DNA synthesis enables NLRP3 inflammasome activation Nature 10 210-215
[2]
Tschopp J(2010)NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production? Nat. Rev. Immunol. undefined undefined-undefined
[3]
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