Proteolysis: from the lysosome to ubiquitin and the proteasome

被引：891

作者：

Ciechanover, A

机构：

[1] Technion Israel Inst Technol, Canc & Vasc Biol Res Ctr, Rappaport Fac Med, IL-31096 Haifa, Israel

[2] Technion Israel Inst Technol, Res Inst, IL-31096 Haifa, Israel

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 01期

关键词：

D O I：

10.1038/nrm1552

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

How the genetic code is translated into proteins was a key focus of biological research before the 1980s, but how these proteins are degraded remained a neglected area. With the discovery of the lysosome, it was suggested that cellular proteins are degraded in this organelle. However, several independent lines of experimental evidence strongly indicated that non-lysosomal pathways have an important role in intracellular proteolysis, although their identity and mechanisms of action remained obscure. The discovery of the ubiquitin - proteasome system resolved this enigma.

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页码：79 / 86

页数：8

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