Entropy measures of heart rate variation in conscious dogs

被引:85
作者
Palazzolo, JA
Estafanous, FG
Murray, PA
机构
[1] Cleveland Clin Fdn, Ctr Anesthesiol Res, Cleveland, OH 44195 USA
[2] Cleveland Clin Fdn, Div Anesthesiol & Crit Care Med, Cleveland, OH 44195 USA
[3] Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 1998年 / 274卷 / 04期
关键词
approximate entropy; symbolic dynamics; autonomic nervous system; propranolol; atropine;
D O I
10.1152/ajpheart.1998.274.4.H1099
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Our goal was to determine the contributions of sympathetic and parasympathetic activity to entropy measures of heart rate variability (HRV). We compared our results with two commonly used methods to analyze HRV: standard deviation (SDNN) and power spectral analysis (HF norm). Beat-by-beat analysis of R-R intervals was performed in conscious dogs. The R-R intervals were analyzed with approximate entropy (ApEn) and entropy of symbolic dynamics (SymDyn) to assess the effects of reducing system complexity. This was achieved by pharmacologically inhibiting sympathetic, parasympathetic, and total autonomic nervous system regulation of heart rate. Three conditions were examined: rest, standing, and systemic hypotension. At rest or standing, sympathetic inhibition (propranolol) had no effect on ApEn or SymDyn, whereas parasympathetic (atropine) and combined (propranolol + atropine) inhibition reduced both entropy measures to near zero. Systemic hypotension reduced both entropy measures in intact dogs. When hypotension was induced after sympathetic inhibition, ApEn was increased compared with hypotension alone, whereas parasympathetic inhibition with hypotension resulted in near-zero ApEn. Changes in the entropy measures of HRV were directionally similar to changes in SDNN and HF norm. These results indicate that the entropy of R-R intervals reflects parasympathetic modulation of heart rate.
引用
收藏
页码:H1099 / H1105
页数:7
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