Human embryonic stem cells: prospects for development

被引：183

作者：

Pera, MF ^{[1
]}

Trounson, AO

机构：

[1] Monash Univ, Monash Inst Reprod & Dev, Clayton, Vic 3168, Australia

[2] Monash Univ, Dept Physiol, Clayton, Vic 3168, Australia

来源：

DEVELOPMENT | 2004年 / 131卷 / 22期

关键词：

D O I：

10.1242/dev.01451

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

It is widely anticipated that human embryonic stem (ES) cells will serve as an experimental model for studying early development in our species, and, conversely, that studies of development in model systems, the mouse in particular, will inform our efforts to manipulate human stem cells in vitro. A comparison of primate and mouse ES cells suggests that a common underlying blueprint for the pluripotent state has undergone significant species-specific modification. As we discuss here, technical advances in the propagation and manipulation of human ES cells have improved our understanding of their growth and differentiation, providing the potential to investigate early human development and to develop new clinical therapies.

引用

页码：5515 / 5525

页数：11

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