High-valent iron(IV)-oxo complexes of heme and non-heme ligands in oxygenation reactions

被引:981
作者
Nam, Wonwoo [1 ]
机构
[1] Ewha Womans Univ, Dept Chem, Div Nanosci, Seoul 120750, South Korea
[2] Ewha Womans Univ, Ctr Biomimet Syst, Seoul 120750, South Korea
关键词
D O I
10.1021/ar700027f
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
High-valent iron(IV)oxo species have been implicated as the key reactive intermediates in the catalytic cycles of dioxygen activation by heme and non-heme iron enzymes. Our understanding of the enzymatic reactions has improved greatly via investigation of spectroscopic and chemical properties of heme and non-heme iron(IV)oxo complexes. In this Account, reactivities of synthetic iron(IV)oxo porphyrin remmove-cation radicals and mononuclear non-heme iron(IV)oxo complexes in oxygenation reactions have been discussed as chemical models of cytochrome P450 and non-heme iron enzymes. These results demonstrate how mechanistic developments in biomimetic research can help our understanding of dioxygen activation and oxygen atom transfer reactions in nature.
引用
收藏
页码:522 / 531
页数:10
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