Localization of the human CXC chemokine subfamily on the long arm of chromosome 4 using radiation hybrids

被引：41

作者：

Modi, WS ^{[1
]}

Chen, ZQ ^{[1
]}

机构：

[1] NCI, Intramural Res Support Program, SAIC Frederick, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA

来源：

GENOMICS | 1998年 / 47卷 / 01期

关键词：

D O I：

10.1006/geno.1997.5100

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

All 12 of the human CXC chemokine genes were physically mapped using gene-specific PCR primers and the GenBridge 4 radiation hybrid panel. Nine genes, PF4, PF4V1, GRO1, GCP2, PPBP, IL8, GRO2, GRO3, and SCYB5 were assigned within a 1.8-cR interval of one another on 4q. Two additional genes, MIG and INP10, map within 0.5 cR of each another and 6 cR distal to the above-mentioned group. The final gene, SDF1, is localized on 10q. Phylogenetic analyses of amino acid sequences revealed that SDF1 is the most divergent member and that the physically separated MIG-INP10 pair constitutes a distinct evolutionary lineage. (C) 1998 Academic Press.

引用

页码：136 / 139

页数：4

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