Induction of heme oxygenase-1 in toxic renal injury: mercuric chloride-induced acute renal failure in rat

被引：17

作者：

Horikawa, S

Ito, K

Ikeda, S

Shibata, T

Ishizuka, S

Yano, T

Hagiwara, K

Ozasa, H

Katsuyama, I

机构：

[1] Tokyo Med & Dent Univ, Inst Med Res, Dept Pathol Biochem, Chiyoda Ku, Tokyo 101, Japan

[2] Tsuchiura Kyodo Hosp, Dept Surg, Tsuchiura, Ibaraki, Japan

[3] Tsuchiura Kyoda Hosp, Dept Pathol, Tsuchiura, Ibaraki, Japan

[4] Tokyo Womens Med Coll, Dept Internal Med 4, Tokyo 162, Japan

[5] Natl Inst Hlth & Nutr, Div Appl Food Res, Tokyo, Japan

[6] Minami Ikebukuro Clin, Tokyo, Japan

[7] Biochem & Pharmaceut Labs Inc, Osaka, Japan

来源：

TOXICOLOGY LETTERS | 1998年 / 94卷 / 01期

关键词：

mercuric chloride; acute renal failure; heme oxygenase-1; toxic renal injury;

D O I：

10.1016/S0378-4274(97)00103-3

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

It is known that mercuric chloride (HgCl2) is a nephrotoxicant. When HgCl2 (1 mg/kg body weight) was intraperitoneally injected into rats, acute renal failure was induced. Histological changes in the kidneys were exclusively observed in the proximal tubules and the severe necrosis was found as early as 24 h after HgCl2 injection. The heme oxygenase-1 (HO-1) mRNA was strongly and promptly induced at about 2.5 h, the earliest time examined and abruptly decreased after the injection. Whereas the time course of HO-1 protein level was delayed as compared with that of HO-1 mRNA level. The levels of HO-I mRNA and protein similarly increased with dose-dependent manner. The localization of HO-1 protein was restricted to the tubule cells. These findings suggest the potential involvement of HO-1 induction in the response to HgCl2-induced acute renal injury. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：57 / 64

页数：8

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