Chemokines in autoimmune diseases

被引：60

作者：

Arimilli, S ^{[1
]}

Ferlin, W ^{[1
]}

Solvason, N ^{[1
]}

Deshpande, S ^{[1
]}

Howard, M ^{[1
]}

Mocci, S ^{[1
]}

机构：

[1] Corixa Corp Inc, Autoimmune Dis Res, Redwood City, CA 94063 USA

来源：

IMMUNOLOGICAL REVIEWS | 2000年 / 177卷

关键词：

D O I：

10.1034/j.1600-065X.2000.17716.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoimmune diseases like multiple sclerosis (MS) and insulin-dependent diabetes (IDD) are believed to be mediated by pathogenic CD4(+) autoreactive T cells which mediate selective destruction of specific host cells. Interrupting the trafficking of such T cells from host circulation to the sites of pathology, such as the central nervous system in the case of MS and the pancreas in the case of IDD, potentially offers a novel opportunity for therapeutic intervention in these diseases. The following summarizes our evolving thoughts on the role of the chemokine network in MS and IDD, and focuses on the chemokine receptor CXCR3 as a potential target for impeding T-cell-mediated destruction in these disease settings.

引用

页码：43 / 51

页数：9

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