Peptide inhibitors of N-Succinyl Diaminopimelic Acid Aminotransferase (DAP-AT): A novel class of antimicrobial compounds.

被引：11

作者：

Cox, RJ ^{[1
]}

Schouten, JA ^{[1
]}

Stentiford, RA ^{[1
]}

Wareing, KJ ^{[1
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(98)00149-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Dipeptide substrates of N-Succinyl Diaminopimelic Acid Aminotransferase (DAP-AT) were converted to hydrazines by treatment with hydrazine and cyanoborohydride. These compounds were tested in vitro as inhibitors of DAP-AT from E. coli and in vivo as antibiotics. The hydrazino-dipeptides showed potent slow binding inhibition of DAP-AT as well as antimicrobial activity. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

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页码：945 / 950

页数：6

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