A truncated variant of the hepatitis C virus core induces a slow but potent immune response in mice following DNA immunization

被引：16

作者：

Dueñas-Carrera, S

Alvarez-Lajonchere, L

Alvarez-Obregón, JC

Herrera, A

Lorenzo, LJ

Pichardo, D

Morales, J

机构：

[1] Ctr Ingn Genet & Biotecnol, Vaccine Div, HCV Dept, Havana, Cuba

[2] Ctr Ingn Genet & Biotecnol, Vaccine Div, AIDS Dept, Havana, Cuba

来源：

VACCINE | 2000年 / 19卷 / 7-8期

关键词：

DNA immunization; HCV core; immune response;

D O I：

10.1016/S0264-410X(00)00209-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vaccination of BALB/c mice with pIDKCo, a plasmid containing the coding sequence for the first 176 amino acids of the hepatitis C virus (HCV) core protein, induced both humoral and cellular specific immune responses. Particularly, the level of anti-core antibodies increased slowly with time up to a mean value above 1:8000 that was generally superior than that found in anti-HCV positive individuals. Six out of nine anti-HCV positive human sera were able to inhibit at different extent the binding of mouse anti-core sera to a recombinant capsid protein. Our results show that it is possible to elicit a potent humoral and cellular immune response against the HCV core antigen in mice following DNA immunization. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：992 / 997

页数：6

共 28 条

[1] LYMPHOCYTE-T RESPONSE TO HEPATITIS-C VIRUS IN DIFFERENT CLINICAL COURSES OF INFECTION [J].