Forecasting Hemoglobinopathy Burden Through Neonatal Screening in Omani Neonates

被引：43

作者：

Alkindi, Salam ^{[2
]}

Al Zadjali, Shoaib ^{[2
]}

Al Madhani, Ali ^{[3
]}

Daar, Shahina ^{[2
]}

Al Haddabi, Hamood ^{[2
]}

Al Abri, Qamariya ^{[2
]}

Gravell, David ^{[2
]}

Berbar, Tsouria ^{[1
]}

Pravin, Sahaya ^{[1
]}

Pathare, Anil ^{[2
]}

Krishnamoorthy, Rajagopal ^{[1
]}

机构：

[1] Hop Robert Debre, INSERM, U763, F-75019 Paris, France

[2] Sultan Qaboos Univ Hosp, Muscat, Oman

[3] Sohar Hosp, Sohar, Oman

来源：

HEMOGLOBIN | 2010年 / 34卷 / 02期

关键词：

GENETIC ABNORMALITIES; ALPHA-THALASSEMIA; BETA-THALASSEMIA; DISEASE;

D O I：

10.3109/03630261003677213

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To evaluate the incidence of hemoglobinopathies in Omani subjects and to forecast its future burden on health resources, we initiated a prospective neonatal screening program in two major cities of the Sultanate of Oman. Consecutive cord blood samples from a total of 7,837 neonates were analyzed for complete blood counts and for hemoglobin (Hb) profile by high performance liquid chromatography (HPLC). No case with Hb H (beta 4) was detected. We observed that the overall incidence of alpha-thalassemia (alpha-thal) was 48.5% [based on the presence of Hb Bart's (gamma 4)] and the beta-globin-related abnormalities accounted for 9.5% of the samples (4.8% sickle cell trait, 2.6% beta-thal trait, 0.9% Hb E trait, 0.8% Hb D trait, 0.08% Hb C trait, 0.3% sickle cell disease and 0.08% homozygous beta-thal). This is also the first large study to establish reference ranges of cord red blood cell (RBC) indices for Omani neonates.</.

引用

页码：135 / 144

页数：10

共 11 条

[1] Effects of increased anionic charge in the β-globin chain on assembly of hemoglobin in vitro [J].