Antiretroviral therapy for children in the routine setting in Malawi

被引：24

作者：

Bell, F. ^{[1
]}

Bong, C. N. ^{[1
]}

Bramson, B. ^{[1
]}

Ellis, J. ^{[1
]}

Fitzgerald, M. ^{[1
]}

Goossens, S. ^{[1
]}

Graham, S. M. ^{[1
]}

Harries, A. D. ^{[1
]}

Hochgesang, M. ^{[1
]}

Jobarteh, K. ^{[1
]}

Kamthunzi, P. ^{[1
]}

Kazembe, R. ^{[1
]}

Libamba, E. ^{[1
]}

Makombe, S. ^{[1
]}

Massaquoi, M. ^{[1
]}

Mhango, E. ^{[1
]}

Molyneux, E. M. ^{[1
]}

Mwansambo, C. ^{[1
]}

Nyang'wa, B.-T. ^{[1
]}

Pasulani, O. ^{[1
]}

Phiri, S. ^{[1
]}

Poerksen, G. ^{[1
]}

Schouten, E. J. ^{[1
]}

Torjesen, K. ^{[1
]}

van Oosterhout, J. J. G. ^{[1
]}

Weigel, R. ^{[1
]}

Yu, J. ^{[1
]}

机构：

[1] Malawi Cty Off, Family Hlth Int, Lilongwe 3, Malawi

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2007年 / 101卷 / 05期

关键词：

HIV; AIDS; antiretroviral therapy; children; Malawi;

D O I：

10.1016/j.trstmh.2006.10.004

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Malawi is scaling up antiretroviral. therapy (ART) for HIV-infected patients. Using a fixed-dose combination of stavudine + lamivudine + nevirapine ('Triomune') as the first-tine regimen, split tablets are given to children with doses according to body weight. By March 2006, a total of 46 702 patients had been started on ART, of whom 2718 (5.8%) were children aged <15 years. In a subset of 935 children, comprising 486 boys and 449 girls, 1.5% were aged <1 year, 26% were aged 1-4 years, 39% were aged 5-9 years and 33% were aged 10-14 years. Between July and September 2005, 7905 patients started ART, comprising 7469 adults and 436 children. Six-month cohort outcomes censored on 31 March 2006 showed significantly more children alive and significantly fewer children dead or defaulted compared with adults. Between January and March 2005, 4580 patients started ART, comprising 4347 adults and 233 children. Twelve-month cohort outcomes censored on 31 March 2006 showed significantly more children alive compared with adults. The results of this national. study should encourage other programmes to invest in ART for children and particularly to monitor their treatment outcomes. (c) 2006 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

引用

页码：511 / 516

页数：6

共 21 条

[1]

[Anonymous], NAT EST HIV AIDS MAL

[2]

[Anonymous], 2003, SCAL ANT THER RES LT

[3]

[Anonymous], TREATM AIDS GUID US

[4]

BARLOWMOSHA L, 2005, 3 INT AIDS SOC C HIV

[5] Antiretroviral treatment in pediatric HIV infection in the United States - From clinical trials to clinical practice [J].

Brogly, S ;

Williams, P ;

Seage, GR ;

Oleske, JM ;

Van Dyke, R ;

McIntosh, K .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 293 (18) :2213-2220

[6]

CHIMZIZI R, 2005, REP COUNTR WID SURV

[7] Pharmacokinetics of nevirapine in HIV-infected children receiving an adult fixed-dose combination of stavudine, lamivudine and nevirapine [J].

Chokephaibulkit, K ;

Plipat, N ;

Cressey, TR ;

Frederix, K ;

Phongsamart, W ;

Capparelli, E ;

Kolladarungkri, T ;

Vanprapar, N .

AIDS, 2005, 19 (14) :1495-1499

[8]

CORBETT A, 2005, 45 INT C ANT AG CHEM

[9]

ELLIS J, 2006, ARCH DIS CHILD S, V91, pA6

[10] Highly active antiretroviral therapies among HIV-1 infected children in Abidjan, Cote d'Ivoire [J].

Fassinou, P ;

Elenga, N ;

Rouet, F ;

Laguide, R ;

Kouakoussui, KA ;

Timite, M ;

Blanche, S ;

Msellati, P .

AIDS, 2004, 18 (14) :1905-1913

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