Irisin: a new molecular marker and target in metabolic disorder

被引：102

作者：

Chen, Jia-qi ^{[1
,2
]}

Huang, Yue-ye ^{[1
]}

Gusdon, Aaron M. ^{[3
]}

Qu, Shen ^{[1
,2
]}

机构：

[1] Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Endocrinol & Metab, Shanghai 200072, Peoples R China

[2] Nanjing Med Univ, Nanjing 210029, Jiangsu, Peoples R China

[3] Weill Cornell Med Coll, Dept Neurol, New York, NY 10065 USA

来源：

LIPIDS IN HEALTH AND DISEASE | 2015年 / 14卷

关键词：

Irisin; Obesity; Metabolic diseases; CIRCULATING IRISIN; INSULIN-RESISTANCE; ENERGY RESTRICTION; DIABETES-MELLITUS; ADIPOSE-TISSUE; SERUM-LEVELS; WEIGHT-LOSS; ASSOCIATION; OBESITY; MASS;

D O I：

10.1186/1476-511X-14-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Irisin is a newly discovered exercise-mediated myokine which regulates energy metabolism and has been the subject of much recent research. Irisin plays an important role in metabolic diseases making it a potential new target to combat obesity and its associated disorders, such as T2DM. However, the results of several recent studies investigating the effects of irisin have been controversial. The present review will introduce the discovery of irisin, the role of irisin in metabolic disorders, possible mechanisms, and unanswered questions for future research.

引用

页数：6

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