Positive and negative regulators for neuronal BC1 RNA transcription by RNA polymerase III are possible members of the RNA polymerase II transcription system

被引：3

作者：

Kobayashi, S ^{[1
]}

Kamo, S ^{[1
]}

Agui, K ^{[1
]}

Funakoshi, T ^{[1
]}

Anzai, K ^{[1
]}

机构：

[1] Nihon Univ, Coll Pharm, Dept Biochem, Funabashi, Chiba 2748555, Japan

来源：

MOLECULAR BRAIN RESEARCH | 2003年 / 111卷 / 1-2期

关键词：

neuronal BC1 RNA; transcription; positive and negative regulation;

D O I：

10.1016/S0169-328X(02)00695-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuronal cell-specific BC1 RNA is a unique RNA polymerase III (Pol 111) transcript. The transcription is controlled by an activator E2 site and by BCRE, a repressor element, in response to neuronal activity. BC1 RNA is localized to dendritic domains as ribonucleoprotein particles, and it has been suggested to play a functional role in translational regulation of dendritic mRNAs. In the present study, using a luciferase assay in NG108-15 cells, we found that the positive and negative regulators for BC1 RNA transcription can also function in the Pol II transcription system. Our results suggest that the neuronal activity-dependent expression of BC1 RNA by Pol III and a subset of neuronal mRNAs by Pol II may be simultaneously controlled by the E2 site and BCRE, as well as their binding proteins. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：211 / 215

页数：5

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