Oligofructose protects against the hypertriglyceridemic and pro-oxidative effects of a high fructose diet in rats

被引:123
作者
Busserolles, J [1 ]
Gueux, E [1 ]
Rock, E [1 ]
Demigné, C [1 ]
Mazur, A [1 ]
Rayssiguier, Y [1 ]
机构
[1] INRA, Ctr Rech Nutr Humaine Auvergne, Unite Malad Metab & Micronutr, Theix, F-63122 St Genes Champanelle, France
关键词
high fructose diet; insulin; leptin; oligofructose; oxidative stress;
D O I
10.1093/jn/133.6.1903
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Recent findings indicate that in addition to its a high fructose diet has a pro-oxidant effect in rats compared with a starch-based diet. Oligofructose (OFS) has already been shown to decrease plasma lipids in rats. We assessed the impact of fructose on oxidative stress by supplementing a high fructose diet with OFS. Rats were fed either a high fructose diet or a starch-based diet, with or without supplementation of 10 g/100 g oligofructose for 4 wk. Regardless of the type of carbohydrate, OFS in the diet produced an enlargement of the cecum and led to a significant increase in the SCFA cecum pool. Fructose feeding . was associated with significantly higher insulin plasma concentraitidhs (+63%) in the control groups, whereas insulin plasma concentrations did not differ in rats fed the fructose diet supplemented with OFS. Plasma leptin concentration was significantly lower (approximate to50%) in the OFS-supplemented fructose group compared with the other three groups. Fructose feeding in rats also significantly increased (P < 0.001) and liver (P < 0.001) triglyceride (TG) concentrations and the addition of OFS prevented the TG accumulation induced by fructose in the liver (P < 0.05) and hyperlipemia (P < 0.05). OFS consumption prevented (P < 0.05) the lower plasma vitamin E/TG ratio in rats fed the fructose diet. Control rats fed the fructose diet had high plasma TBARS values compared with rats fed the starch diet, whereas TBARS values remained unchanged when rats were supplemented with OFS. Control rats fed the fructose diet had higher TBARS urine values and higher heart tissue susceptibility to peroxidation compared with rats fed the starch diet, and this effect was significantly reduced by OFS consumption. Further studies are required to identify the mechanisms underlying, the protective effect of OFS against the pro-oxidant effect of fructose. However, the potential nutritional benefits of OFS supplementation in fructose-rich diets are suggested.
引用
收藏
页码:1903 / 1908
页数:6
相关论文
共 38 条
[1]   Metformin improves lipid metabolism and attenuates lipid peroxidation in high fructose-fed rats [J].
Anurag, P ;
Anuradha, CV .
DIABETES OBESITY & METABOLISM, 2002, 4 (01) :36-42
[2]  
Bantle JP, 2000, AM J CLIN NUTR, V72, P1128
[3]  
Bergmeyer HU, 1974, METHOD ENZYMAT AN, P1196
[4]  
BIERI JG, 1977, J NUTR, V107, P1394
[5]   Oxidant stress:: the role of nutrients in cell-lipoprotein interactions [J].
Blache, D ;
Gesquière, L ;
Loreau, N ;
Durand, P .
PROCEEDINGS OF THE NUTRITION SOCIETY, 1999, 58 (03) :559-563
[6]   Rats fed a high sucrose diet have altered heart antioxidant enzyme activity and gene expression [J].
Busserolles, J ;
Zimowska, W ;
Rock, E ;
Rayssiguier, Y ;
Mazur, A .
LIFE SCIENCES, 2002, 71 (11) :1303-1312
[7]   Short-term consumption of a high-sucrose diet has a pro-oxidant effect in rats [J].
Busserolles, J ;
Rock, E ;
Gueux, E ;
Mazur, A ;
Grolier, P ;
Rayssiguier, Y .
BRITISH JOURNAL OF NUTRITION, 2002, 87 (04) :337-342
[8]   Selected indigestible oligosaccharides affect large bowel mass, cecal and fecal short-chain fatty acids, pH and microflora in rats [J].
Campbell, JM ;
Fahey, GC ;
Wolf, BW .
JOURNAL OF NUTRITION, 1997, 127 (01) :130-136
[9]  
Delzenne NM, 2001, AM J CLIN NUTR, V73, p456S, DOI 10.1093/ajcn/73.2.456s
[10]   Biochemical basis of oligofructose-induced hypolipidemia in animal models [J].
Delzenne, NM ;
Kok, NN .
JOURNAL OF NUTRITION, 1999, 129 (07) :1467S-1470S