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Hypothesis-review -: An alternative model of the twin arginine translocation system
被引:98
作者:

Brüser, T
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机构: Univ Halle Wittenberg, Inst Mikrobiol, D-06120 Halle An Der Saale, Germany

Sanders, C
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机构: Univ Halle Wittenberg, Inst Mikrobiol, D-06120 Halle An Der Saale, Germany
机构:
[1] Univ Halle Wittenberg, Inst Mikrobiol, D-06120 Halle An Der Saale, Germany
[2] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA
关键词:
D O I:
10.1078/0944-5013-00176
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
The twin arginine translocation (Tat) system is a machinery which can translocate folded proteins across energy transducing membranes. Currently it is supposed that Tat substrates bind directly to Tat translocon components before a DeltapH-driven translocation occurs. In this review, an alternative model is presented which proposes that membrane integration could precede Tat-dependent translocation. This idea is mainly supported by the recent observations of Tat-independent membrane insertion of Tat substrates in vivo and in vitro. Membrane insertion may allow i) a quality control of the folded state by membrane bound proteases like FtsH, ii) the recognition of the membrane spanning signal peptide by Tat system components, and iii) a pulling mechanism of translocation. In some cases of folded Tat substrates, the membrane targeting process may require ATP-dependent N-terminal unfolding-steps.
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页码:7 / 17
页数:11
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