Scabrosin esters and derivatives: chemical derivatization studies and biological evaluation

被引：17

作者：

Chai, CLL ^{[1
]}

Elix, JA ^{[1
]}

Huleatt, PB ^{[1
]}

Waring, P ^{[1
]}

机构：

[1] Australian Natl Univ, Dept Chem, Ctr Study Bioact Mol, Canberra, ACT 0200, Australia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 22期

基金：

澳大利亚研究理事会;

关键词：

anti-proliferative agents; anti-tumour compounds; natural products; polycyclic heterocyclic compounds;

D O I：

10.1016/j.bmc.2004.08.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several derivatives of the natural scabrosin esters were synthesized in order to elucidate the structural features present, which are responsible for the biological activities. The studies demonstrate that full anti-proliferative activities of the scabrosin esters, both the carboskeleton core as well as the ability to form the dithiol and/or the disulfide linkage of the epidithiopiperazine-2,5-dione are required. The presence of the epoxide rings on the scabrosin esters do not contribute to the observed biological activities. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5991 / 5995

页数：5

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