An improved neuroanatomical model of the default-mode network reconciles previous neuroimaging and neuropathological findings

被引：253

作者：

Alves, Pedro Nascimento ^{[1
,2
,3
,4
]}

Foulon, Chris ^{[1
,2
,5
]}

Karolis, Vyacheslav ^{[1
,2
,6
]}

Bzdok, Danilo ^{[7
,8
,9
,10
]}

Margulies, Daniel S. ^{[1
,2
]}

Volle, Emmanuelle ^{[1
,2
]}

de Schotten, Michel Thiebaut ^{[1
,2
,11
,12
]}

机构：

[1] Sorbonne Univ, Brain Connect & Behav Lab, BCBlab, Paris, France

[2] Inst Cerveau & Moelle Epiniere ICM, Frontlab, UPMC UMRS 1127, Inserm U1127,CNRS,UMR 7225, Paris, France

[3] Hosp Santa Maria, CHULN, Dept Neurosci & Mental Hlth, Neurol, Lisbon, Portugal

[4] Univ Lisbon, Fac Med, Language Res Lab, Lisbon, Portugal

[5] Univ Texas Austin, Computat Neuroimaging Lab, Dept Diagnost Med, Dell Med Sch, Austin, TX 78712 USA

[6] Univ Oxford, John Radcliffe Hosp, FMRIB Ctr, Oxford, England

[7] INRIA, Parietal Team, Saclay, France

[8] CEA, Neurospin, Gif Sur Yvette, France

[9] Rhein Westfal TH Aachen, Dept Psychiat Psychotherapy & Psychosomat, Aachen, Germany

[10] JARA, BRAIN, Julich, Germany

[11] Grp Hosp Pitie Salpetriere, Ctr Neuroimagerie Rech CENIR, Paris, France

[12] Univ Bordeaux, CNRS, CEA,UMR 5293, Grp Imagerie Neurofonct,Inst Malad Neurodegenerat, Bordeaux, France

来源：

COMMUNICATIONS BIOLOGY | 2019年 / 2卷 / 1期

基金：

欧洲研究理事会;

关键词：

TEMPORAL-LOBE EPILEPSY; HUMAN CEREBRAL-CORTEX; FUNCTIONAL CONNECTIVITY; RESTING-STATE; ALZHEIMERS-DISEASE; NUCLEUS-ACCUMBENS; AUTOBIOGRAPHICAL MEMORY; THALAMIC-STIMULATION; ANTERIOR NUCLEUS; HUMAN CEREBELLUM;

D O I：

10.1038/s42003-019-0611-3

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

The brain is constituted of multiple networks of functionally correlated brain areas, out of which the default-mode network (DMN) is the largest. Most existing research into the DMN has taken a corticocentric approach. Despite its resemblance with the unitary model of the limbic system, the contribution of subcortical structures to the DMN may be underappreciated. Here, we propose a more comprehensive neuroanatomical model of the DMN including subcortical structures such as the basal forebrain, cholinergic nuclei, anterior and mediodorsal thalamic nuclei. Additionally, tractography of diffusion-weighted imaging was employed to explore the structural connectivity, which revealed that the thalamus and basal forebrain are of central importance for the functioning of the DMN. The contribution of these neurochemically diverse brain nuclei reconciles previous neuroimaging with neuropathological findings in diseased brains and offers the potential for identifying a conserved homologue of the DMN in other mammalian species.

引用

页数：14

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