Role of Cytokines as Mediators and Regulators of Microglial Activity in Inflammatory Demyelination of the CNS

被引：73

作者：

Merson, Tobias D. ^{[1
,2
]}

Binder, Michele D. ^{[1
,2
]}

Kilpatrick, Trevor J. ^{[1
,2
]}

机构：

[1] Univ Melbourne, Florey Neurosci Inst, Parkville, Vic 3010, Australia

[2] Univ Melbourne, Ctr Neurosci, Parkville, Vic 3010, Australia

来源：

NEUROMOLECULAR MEDICINE | 2010年 / 12卷 / 02期

关键词：

Microglia; Macrophages; Innate immunity; Cytokines; Interleukins; Interferons; Inflammatory demyelination; Multiple Sclerosis; Experimental autoimmune encephalomyelitis (EAE); Remyelination; Oligodendrocyte; Myelin; TUMOR-NECROSIS-FACTOR; CENTRAL-NERVOUS-SYSTEM; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; GROWTH-FACTOR-BETA; COLONY-STIMULATING FACTOR; LEUKEMIA INHIBITORY FACTOR; NITRIC-OXIDE SYNTHASE; MULTIPLE-SCLEROSIS LESIONS; MESSENGER-RNA EXPRESSION;

D O I：

10.1007/s12017-010-8112-z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

As the resident innate immune cells of the central nervous system (CNS), microglia fulfil a critical role in maintaining tissue homeostasis and in directing and eliciting molecular responses to CNS damage. The human disease Multiple Sclerosis and animal models of inflammatory demyelination are characterized by a complex interplay between degenerative and regenerative processes, many of which are regulated and mediated by microglia. Cellular communication between microglia and other neural and immune cells is controlled to a large extent by the activity of cytokines. Here we review the role of cytokines as mediators and regulators of microglial activity in inflammatory demyelination, highlighting their importance in potentiating cell damage, promoting neuroprotection and enhancing cellular repair in a context-dependent manner.

引用

页码：99 / 132

页数：34

共 455 条

[1] Functional diversity of helper T lymphocytes [J].