Methionine synthase genetic polymorphism MS A2756G alters susceptibility to follicular but not diffuse large B-cell non-Hodgkin's lymphoma or multiple myeloma

被引：56

作者：

Lincz, LF

Scorgie, FE

Kerridge, I

Potts, R

Spencer, A

Enno, A

机构：

[1] Newcastle Mater Misericordiae Hosp, Hunter Haematol Res Grp, Waratah, NSW 2298, Australia

[2] Monash Univ, Monash Univ Med Sch,Alfred Hosp, Dept Clin Haematol & Bone Marrow Transplantat, Myeloma Res Grp, Clayton, Vic 3168, Australia

[3] Monash Univ, Monash Univ Med Sch, Alfred Hosp, Dept Med, Clayton, Vic 3168, Australia

[4] Hunter Area Pathol Serv, Newcastle, NSW, Australia

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2003年 / 120卷 / 06期

关键词：

methionine synthase; MTHFR; polymorphisms; non-Hodgkin's lymphoma; multiple myeloma;

D O I：

10.1046/j.1365-2141.2003.04220.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Lymphoproliferative diseases are characterized by chromosomal aberrations, and susceptibility may depend on inherited activity of enzymes required for DNA synthesis and methylation. We analysed genetic polymorphisms for methionine synthase (MS) A2756G, methylenetetrahydrofolate reductase (MTHFR) C677T and MTHFR A1298C in Caucasians with non-Hodgkin's lymphoma (NHL; n = 151), multiple myeloma (MM; n = 90) and 299 control subjects. The MS 2756 AG/GG genotypes were significantly under-represented in NHL (26.2%) vs control subjects (37.2%; P = 0.02), and conferred a 2.4-fold lower risk of follicular (odds ratio = 0.41, 95% confidence interval: 0.19-0.88, p = 0.02) but not diffuse large B-cell lymphoma. MM patients showed no significant difference in the polymorphisms compared with control subjects.

引用

页码：1051 / 1054

页数：4

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