The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

被引：3423

作者：

Coppe, Jean -Philippe ^{[1
]}

Desprez, Pierre-Yves ^{[2
,3
]}

Krtolica, Ana ^{[1
]}

Campisi, Judith ^{[1
,2
]}

机构：

[1] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA

[2] Ruck Inst Age Res, Novato, CA 94945 USA

[3] Calif Pacific Med Ctr, Canc Res Inst, San Francisco, CA 94107 USA

来源：

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE | 2010年 / 5卷

关键词：

aging; cancer; inflammation; proliferation; invasion; PLASMINOGEN-ACTIVATOR INHIBITOR; ONCOGENE-INDUCED SENESCENCE; PANCREATIC-CANCER CELLS; TISSUE GROWTH-FACTOR; CELLULAR SENESCENCE; REPLICATIVE SENESCENCE; HUMAN FIBROBLASTS; GENE-EXPRESSION; ENDOTHELIAL-CELLS; PREMATURE SENESCENCE;

D O I：

10.1146/annurev-pathol-121808-102144

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at risk for malignant transformation. However, accumulating evidence shows that senescent cells can have deleterious effects on the tissue microenvironment. The most significant of these effects is the acquisition of a senescence-associated secretor phenotype (SASP) that turns senescent fibroblasts into proinflammatory cells that have the ability to promote tumor progression.

引用

页码：99 / 118

页数：20

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