Polycythemia vera responds to imatinib mesylate

被引：29

作者：

Jones, CM

Dickinson, TM

机构：

[1] Germantown, TN 38138

来源：

AMERICAN JOURNAL OF THE MEDICAL SCIENCES | 2003年 / 325卷 / 03期

关键词：

c-kit; polycythemia vera; imatinib mesylate;

D O I：

10.1097/00000441-200303000-00007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report 2 patients with polycythemia vera who were demonstrated to be bcr/abl-negative and were unable to tolerate either hydroxyurea or interferon-a but who had excellent clinical responses to imatinib mesylate (STI-571). This effect is consistent with the inhibitory effect of imatinib mesylate on c-kit's tyrosine kinase activity as demonstrated by its effectiveness in patients with gastrointestinal stromal tumors.

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收藏

页码：149 / 152

页数：4

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