Protein heterodimerization through ligand-bridged multivalent pre-organization: Enhancing ligand binding toward both protein targets

被引：28

作者：

Liu, JY

Zhang, ZS

Tan, XJ

Hol, WGJ

Verlinde, CLMJ

Fan, EK ^{[1
]}

机构：

[1] Univ Washington, Dept Biochem, Biomol Struct Ctr, Seattle, WA 98195 USA

[2] Univ Washington, Dept Biol Struct, Seattle, WA 98195 USA

[3] Univ Washington, Dept Chem, Seattle, WA 98195 USA

[4] Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 07期

关键词：

D O I：

10.1021/ja043817r

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Structure-based design of a bifunctional ligand for two protein pentamers, cholera toxin B pentamer (CTB) and human serum amyloid P component (SAP), leads to multivalent dimerization of CTB and SAP in solution. This multivalent heterodimerization of proteins significantly enhances the affinity of the bifunctional ligand toward both target proteins. Copyright © 2005 American Chemical Society.

引用

页码：2044 / 2045

页数：2

共 24 条

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