Recombinant HDL-like nanoparticles: A specific contrast agent for MRI of atherosclerotic plaques

被引：252

作者：

Frias, JC

Williams, KJ

Fisher, EA ^{[1
]}

Fayad, ZA

机构：

[1] Mt Sinai Sch Med, Imaging Sci Labs, Dept Radiol, New York, NY USA

[2] Mt Sinai Sch Med, Zena & Michael A Wiener Cardiovasc Inst, New York, NY USA

[3] CUNY, Sch Med, New York, NY 10029 USA

[4] Thomas Jefferson Univ, Philadelphia, PA 19107 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 50期

关键词：

D O I：

10.1021/ja044911a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new contrast agent for MRI based on recombinant HDL-like nanoparticles has been prepared. It shows a great potential as a contrast agent for atherosclerotic plaques in a relative short time (24 h post-injection) as it is selective for the plaques and is an endogenous molecule. It also can distinguish between different types of plaques as the enhancement obtained is different, depending on plaque composition. Copyright © 2004 American Chemical Society.

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收藏

页码：16316 / 16317

页数：2

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