Oncogene addiction: Sometimes a temporary slavery

被引：55

作者：

Jonkers, J

Berns, A

机构：

[1] Netherlands Canc Inst, Ctr Biomed Genet, Div Mol Genet, NL-1066 CX Amsterdam, Netherlands

[2] Netherlands Canc Inst, Ctr Biomed Genet, Div Mol Biol, NL-1066 CX Amsterdam, Netherlands

来源：

CANCER CELL | 2004年 / 6卷 / 06期

关键词：

D O I：

10.1016/S1535-6108(04)00339-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumors induced in conditional oncomice can show remarkable different responses to subsequent oncogene deprivation. Complete sustained regression, concomitant with massive differentiation and/or apoptosis, and partial regression are both observed. In the latter case, tumor growth either resumes without being dependent any longer on the oncogene, or requires reactivation of the oncogene in cells that have become dormant. These models reflect many of the features we also witness in human cancer and can therefore assist us in understanding the underlying mechanisms and in designing more effective treatment protocols.

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收藏

页码：535 / 538

页数：4

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