NOVEL SYNTHESIS OF 2-ALKOXY(ARALKOXY)-5-CHLORO[1,2,4]TRIAZOLO[1,5-a]QUINAZOLINES AND THEIR DERIVATIVES

被引：13

作者：

Al-Salahi, Rashad ^{[1
]}

Geffken, Detlef ^{[2
]}

机构：

[1] King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, Riyadh 11451, Saudi Arabia

[2] Univ Hamburg, Inst Pharm, Pharmaceut Chem Div, D-20146 Hamburg, Germany

来源：

HETEROCYCLES | 2010年 / 81卷 / 08期

关键词：

Oxalyl Chloride; Phosphoryl Chloride; Hydrazine Hydrate; Hydrazide and Carbazide; Sodium Azide; BENZODIAZEPINE; BINDING;

D O I：

10.3987/COM-10-11976

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

2-Alkoxy(aralkoxy)-5-chloro[1,2,4]triazolo[1,5-a]quinazolines have been synthesized. The corresponding 2-alkoxy(aralkoxy)[1,2,4]triazolo[1,5-a]quinazolin-5-ones were chlorinated with either oxalyl chloride or phosphorus oxychloride. The chlorine atom at 5-position of the targeted [1,2,4]triazolo[1,5-a]quinazolines was replaced with multifunctional N-nucleophiles. This provided the preparation of the heterocyclic system bearing a variety of substituents at 5-position.

引用

页码：1843 / 1859

页数：17

共 12 条

[1]

CHEMISTRY OF QUINAZOLINES - REINVESTIGATION OF THE ACTION OF HYDRAZINE ON THIOXO DERIVATIVES [J].

BADAWY, MA ;

ABDELHADY, SAL ;

IBRAHIM, YA ;

KADRY, AM .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1985, 22 (06) :1535-1536

[2]

Bereznak JF, 2008, Preparation of fungicidal tricyclic 1,2,4-triazoles, Patent No. [WO 2008103357 A1 20080828, 2008103357, WO 2008103357, A1 20080828]

[3]

Substituted 1,2,3-triazolo[1,5-a]quinazolines: synthesis and binding to benzodiazepine and adenosine receptors [J].