KIDNEY CANCER Neoadjuvant targeted therapies in renal cell carcinoma

被引：9

作者：

Ficarra, Vincenzo ^{[1
]}

Novara, Giacomo ^{[1
]}

机构：

[1] Univ Padua, Urol Clin, Dept Oncol & Surg Sci, I-35128 Padua, Italy

来源：

NATURE REVIEWS UROLOGY | 2010年 / 7卷 / 02期

关键词：

CYTOREDUCTIVE NEPHRECTOMY; INTERFERON-ALPHA;

D O I：

10.1038/nrurol.2010.2

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Neoadjuvant targeted therapy can be used in patients with unresectable locally advanced, locally recurrent or metastatic renal cell carcinoma to induce cytoreduction before surgical resection. The efficacy of this multimodal therapy is still unproven, however, and must be balanced against a potential higher risk of perioperative complications.

引用

页码：63 / 64

页数：2

共 10 条

[1] Preoperative tyrosine kinase inhibition as an adjunct to debulking nephrectomy [J].

Amin, Chirag ;

Wallen, Eric ;

Pruthi, Raj S. ;

Calvo, Benjamin F. ;

Godley, Paul A. ;

Rathmell, W. Kimryn .

UROLOGY, 2008, 72 (04) :864-868

[2] Neoadjuvant sunitinib for surgically complex advanced renal cell cancer of doubtful resectability: initial experience with downsizing to reconsider cytoreductive surgery [J].

Bex, Axel ;

van der Veldt, Astrid A. M. ;

Blank, Christian ;

van den Eertwegh, Alfons J. M. ;

Boven, Epie ;

Horenblas, Simon ;

Haanen, John .

WORLD JOURNAL OF UROLOGY, 2009, 27 (04) :533-539

[3] Sorafenib in advanced clear-cell renal-cell carcinoma [J].

Escudier, Bernard ;

Eisen, Tim ;

Stadler, Walter M. ;

Szczylik, Cezary ;

Oudard, Stephane ;

Siebels, Michael ;

Negrier, Sylvie ;

Chevreau, Christine ;

Solska, Ewa ;

Desai, Apurva A. ;

Rolland, Frederic ;

Demkow, Tomasz ;

Hutson, Thomas E. ;

Gore, Martin ;

Freeman, Scott ;

Schwartz, Brian ;

Shan, Minghua ;

Simantov, Ronit ;

Bukowski, Ronald M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (02) :125-134

[4] Cytoreductive nephrectomy in patients with metastatic renal cancer: A combined analysis [J].

Flanigan, RC ;

Mickisch, G ;

Sylvester, R ;

Tangen, C ;

Van Poppel, H ;

Crawford, ED .

JOURNAL OF UROLOGY, 2004, 171 (03) :1071-1076

[5] Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma [J].

Hudes, Gary ;

Carducci, Michael ;

Tomczak, Piotr ;

Dutcher, Janice ;

Figlin, Robert ;

Kapoor, Anil ;

Staroslawska, Elzbieta ;

Sosman, Jeffrey ;

McDermott, David ;

Bodrogi, Istvan ;

Kovacevic, Zoran ;

Lesovoy, Vladimir ;

Schmidt-Wolf, Ingo G. H. ;

Barbarash, Olga ;

Gokmen, Erhan ;

O'Toole, Timothy ;

Lustgarten, Stephanie ;

Moore, Laurence ;

Motzer, Robert J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (22) :2271-2281

[6] Neoadjuvant sutent induction therapy may effectively down-stage renal cell carcinoma atrial thrombi [J].

Karakiewicz, Pierre I. ;

Suardi, Nazareno ;

Jeldres, Claudio ;

Audet, Pascale ;

Ghosn, Pierre ;

Patard, Jean-Jacques ;

Perrotte, Paul .

EUROPEAN UROLOGY, 2008, 53 (04) :845-848

[7] Surgical morbidity associated with administration of targeted molecular therapies before cytoreductive nephrectomy or resection of locally recurrent renal cell carcinoma [J].

Margulis, Vitaly ;

Matin, Surena F. ;

Tannir, Nizar ;

Tamboli, Pheroze ;

Swanson, David A. ;

Jonasch, Eric ;

Wood, Christopher G. .

JOURNAL OF UROLOGY, 2008, 180 (01) :94-98

[8] Sunitinib versus interferon alfa in metastatic renal-cell carcinoma [J].

Motzer, Robert J. ;

Hutson, Thomas E. ;

Tomczak, Piotr ;

Michaelson, M. Dror ;

Bukowski, Ronald M. ;

Rixe, Olivier ;

Oudard, Stephane ;

Negrier, Sylvie ;

Szczylik, Cezary ;

Kim, Sindy T. ;

Chen, Isan ;

Bycott, Paul W. ;

Baum, Charles M. ;

Figlin, Robert A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (02) :115-124

[9] Neoadjuvant targeted therapy and advanced kidney cancer: observations and implications for a new treatment paradigm [J].

Shuch, Brian ;

Riggs, Stephen B. ;

LaRochelle, Jeff C. ;

Kabbinavar, Fairooz F. ;

Avakian, Raffi ;

Pantuck, Allan J. ;

Patard, Jean-Jacques ;

Belldegrun, Arie S. .

BJU INTERNATIONAL, 2008, 102 (06) :692-696

[10] Surgical Resection of Renal Cell Carcinoma After Targeted Therapy [J].

Thomas, Anil A. ;

Rini, Brian I. ;

Stephenson, Andrew J. ;

Garcia, Jorge A. ;

Fergany, Amr ;

Krishnamurthi, Venkatesh ;

Novick, Andrew C. ;

Gill, Inderbir S. ;

Klein, Eric A. ;

Zhou, Ming ;

Campbell, Steven C. .

JOURNAL OF UROLOGY, 2009, 182 (03) :881-886

← 1 →