Successful sublingual immunotherapy with birch pollen has limited effects on concomitant food allergy to apple and the immune response to the Bet v 1 homolog Mal d 1

被引:118
作者
Kinaciyan, Tamar
Jahn-Schmid, Beatrice
Radakovics, Astrid
Zwoelfer, Bettina
Schreiber, Claudia
Francis, James N.
Ebner, Christof
Bohle, Barbara
机构
[1] Med Univ Vienna, Ctr Physiol & Pathophysiol, Dept Pathophysiol, A-1090 Vienna, Austria
[2] Med Univ Vienna, Div Immunol Allergy & Infect Dis, Dept Dermatol, A-1090 Vienna, Austria
[3] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England
基金
奥地利科学基金会;
关键词
birch pollen allergy; Bet v 1; food allergy; oral allergy syndrome; sublingual immunotherapy; cross-reactivity;
D O I
10.1016/j.jaci.2006.11.010
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Background: Cross-reactivity between the major birch pollen allergen, Bet v 1. and the apple protein, Mal d 1, frequently causes food allergy. Objective: To investigate the effects of successful sublingual immunotherapy (SLIT) with birch pollen extract on apple allergy and the immune response to Bet v I and Mal d 1. Methods: Before and after 1 year of SLIT, Bet v 1-sensitized patients with oral allergy syndrome to apple underwent nasal challenges with birch pollen and double-blind placebo-controlled food challenges with apple. Bet v 1-specific and Mal d I-specific serum antibody levels and proliferation in PBMCs and allergen-specific T-cell lines (TCLs) were determined. Bet v I-specific TCLs were mapped for T-cell epitopes. Results: In 9 patients with improved nasal provocation scores to birch pollen, apple-induced oral allergy syndrome was not significantly, reduced. Bet v I-specific IgE and IgG(4) levels significantly increased. Bet v I-specific T-cell responses to all epitopes and those cross-reactive with Mal d I significantly decreased. However, neither Mal d I-specific IgE and IgG4 levels nor Mal d I-induced T-cell proliferation changed significantly. In contrast, Mal d I-specific TCLs showed increased responses to Mal d 1 after I year of SLIT. Conclusion: This longitudinal study indicates that pollen SLIT does not efficiently alter the immune response to pollen-related food allergens. which may explain why pollen-associated food allergy is frequently not ameliorated by pollen immunotherapy even if respiratory symptoms significantly improve. Clinical implications: SLIT with birch pollen may have no clinical effect on associated apple allergy.
引用
收藏
页码:937 / 943
页数:7
相关论文
共 33 条
[1]   Effects of birch pollen SIT on apple allergy: a matter of dosage? [J].
Asero, R .
ALLERGY, 2004, 59 (12) :1269-1271
[2]  
Asero R, 1998, CLIN EXP ALLERGY, V28, P1368, DOI 10.1046/j.1365-2222.1998.00399.x
[3]   How long does the effect of birch pollen injection SIT on apple allergy last? [J].
Asero, R .
ALLERGY, 2003, 58 (05) :435-438
[4]   Absorption and distribution kinetics of the major Parietaria judaica allergen (Par j 1) administered by noninjectable routes in healthy human beings [J].
Bagnasco, M ;
Mariani, G ;
Passalacqua, G ;
Motta, C ;
Bartolomei, M ;
Falagiani, P ;
Mistrello, G ;
Canonica, GW .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1997, 100 (01) :122-129
[5]   Characterization of the T cell response to the major hazelnut allergen, Cor a 1.04:: evidence for a relevant T cell epitope not cross-reactive with homologous pollen allergens [J].
Bohle, B ;
Radakovics, A ;
Lüttkopf, D ;
Jahn-Schmid, B ;
Vieths, S ;
Ebner, C .
CLINICAL AND EXPERIMENTAL ALLERGY, 2005, 35 (10) :1392-1399
[6]   Bet v 1, the major birch pollen allergen, initiates sensitization to Api g 1, the major allergen in celery: evidence at the T cell level [J].
Bohle, B ;
Radakovics, A ;
Jahn-Schmid, B ;
Hoffmann-Sommergruber, K ;
Fischer, GF ;
Ebner, C .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2003, 33 (12) :3303-3310
[7]   Cooking birch pollen-related food:: Divergent consequences for IgE- and T cell-mediated reactivity in vitro and in vivo [J].
Bohle, Barbara ;
Zwoelfer, Bettina ;
Heratizadeh, Annice ;
Jahn-Schmid, Beatrice ;
Antonia, Yuliya Dall ;
Alter, Mareike ;
Keller, Walter ;
Zuidmeer, Laurian ;
van Ree, Ronald ;
Werfel, Thomas ;
Ebner, Christof .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 118 (01) :242-249
[8]   Efficacy of birch-pollen immunotherapy on cross-reactive food allergy confirmed by skin tests and double-blind food challenges [J].
Bolhaar, STHP ;
Tiemessen, MM ;
Zuidmeer, L ;
van Leeuwen, A ;
Hoffmann-Sommergruber, K ;
Bruijnzeel-Koomen, CAFM ;
Taams, LS ;
Knol, EF ;
van Hoffen, E ;
van Ree, R ;
Knulst, AC .
CLINICAL AND EXPERIMENTAL ALLERGY, 2004, 34 (05) :761-769
[9]   Sublingual immunotherapy: from proven prevention to putative rapid relief of allergic symptoms [J].
Bousquet, J .
ALLERGY, 2005, 60 (01) :1-3
[10]   Sublingual immunotherapy: Validated! [J].
Bousquet, Jean .
ALLERGY, 2006, 61 :5-6