Phosphocholine of pneumococcal teichoic acids: role in bacterial physiology and pneumococcal infection

被引：50

作者：

Fischer, W ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Fak Med, Inst Biochem, D-91054 Erlangen, Germany

来源：

RESEARCH IN MICROBIOLOGY | 2000年 / 151卷 / 06期

关键词：

lipoteichoic acid; teichoic acid; phosphocholine; pneumococcus;

D O I：

10.1016/S0923-2508(00)00174-1

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Pneumococci have an absolute nutritional requirement for choline. Choline is incorporated as phosphocholine (PCho) into lipoteichoic (LTA) and teichoic acid (TA). The PCho residues are required for transformability, the activity of autolysins, tl-le separation of daughter cells after cell division and for anchoring a family of surface proteins which play important roles in pneumococcal infection. The genes encoding the enzymes for PCho incorporation are described. Two strains that acquired the ability to grow in the absence of choline are discussed. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

引用

页码：421 / 427

页数：7

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