Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)

被引：156

作者：

Franke, Andre ^{[1
]}

Balschun, Tobias ^{[1
]}

Sina, Christian ^{[2
,3
]}

Ellinghaus, David ^{[1
]}

Haesler, Robert ^{[1
]}

Mayr, Gabriele ^{[4
]}

Albrecht, Mario ^{[4
]}

Wittig, Michael ^{[1
]}

Buchert, Eva ^{[1
]}

Nikolaus, Susanna ^{[2
,3
]}

Gieger, Christian ^{[5
]}

Wichmann, H. Erich ^{[5
,6
,7
]}

Sventoraityte, Jurgita ^{[8
]}

Kupcinskas, Limas ^{[8
]}

Onnie, Clive M. ^{[9
]}

Gazouli, Maria ^{[10
]}

Anagnou, Nicholas P. ^{[10
]}

Strachan, David ^{[11
]}

McArdle, Wendy L. ^{[12
]}

Mathew, Christopher G. ^{[9
]}

Rutgeerts, Paul ^{[13
]}

Vermeire, Severine ^{[13
]}

Vatn, Morten H. ^{[14
,15
]}

Krawczak, Michael ^{[16
]}

Rosenstiel, Philip ^{[1
]}

Karlsen, Tom H. ^{[15
]}

Schreiber, Stefan ^{[1
,3
]}

机构：

[1] Univ Kiel, Inst Clin Mol Biol, Univ Hosp Schleswig Holstein, Kiel, Germany

[2] Univ Kiel, PopGen Biobank, Univ Hosp Schleswig Holstein, Kiel, Germany

[3] Univ Kiel, Dept Gen Internal Med, Univ Hosp Schleswig Holstein, Kiel, Germany

[4] Max Planck Inst Informat, Saarbrucken, Germany

[5] German Res Ctr Environm Hlth, Helmholtz Ctr Munich, Inst Epidemiol, Neuherberg, Germany

[6] Univ Munich, Inst Med Informat Biometry & Epidemiol, Munich, Germany

[7] Univ Munich, Klinikum Grosshadern, D-8000 Munich, Germany

[8] Kaunas Univ Med, Dept Gastroenterol, Kaunas, Lithuania

[9] Kings Coll London, Sch Med, Dept Med & Mol Genet, London WC2R 2LS, England

[10] Univ Athens, Sch Med, Dept Biol, GR-11527 Athens, Greece

[11] St Georges Univ, Div Community Hlth Sci, London, England

[12] Univ Bristol, Dept Social Med, Avon Longitudinal Study Parents & Children, Bristol, Avon, England

[13] Univ Hosp Gasthuisberg, Dept Gastroenterol, B-3000 Leuven, Belgium

[14] Akershus Univ Hosp, Fac Med, Oslo, Norway

[15] Univ Hosp, Rikshosp, Dept Med, Oslo, Norway

[16] Univ Kiel, Inst Med Informat & Stat, Kiel, Germany

来源：

NATURE GENETICS | 2010年 / 42卷 / 04期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

INFLAMMATORY-BOWEL-DISEASE; SUSCEPTIBILITY; BTNL2;

D O I：

10.1038/ng.553

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We performed a genome-wide association analysis of 1,897,764 SNPs in 1,043 German ulcerative colitis (UC) cases and 1,703 controls. We discovered new associations at chromosome 7q22 (rs7809799) and at chromosome 22q13 in IL17REL (rs5771069) and confirmed these associations in six replication panels (2,539 UC cases and 5,428 controls) from different regions of Europe (overall study sample P(rs7809799) = 8.81 x 10(-11) and P(rs5771069) = 4.21 x 10(-8), respectively).

引用

页码：292 / 294

页数：3

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