Can left prefrontal rTMS be used as a maintenance treatment for bipolar depression?

被引:77
作者
Li, XB
Nahas, Z
Anderson, B
Kozel, EA
George, MS
机构
[1] Med Univ S Carolina, Inst Psychiat, Brain Stimulat Lab, Charleston, SC 29425 USA
[2] Ralph H Johnson VA Med Ctr, Charleston, SC USA
关键词
D O I
10.1002/da.20027
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Numerous studies have examined the acute antidepressant effects of prefrontal transcranial magnetic stimulation (TMS). However, there is little information on whether TMS can be used as a maintenance treatment to maintain normal mood once subjects have responded. We describe seven adults with bipolar depression who responded acutely to TMS and were then treated with TMS weekly for up to 1 year. TMS was carried out over the left prefrontal cortex at 110% motor threshold, 5 Hz for 8 s for 40 trains. Three subjects completed 1 full year of weekly TMS with an average Hamilton Rating Scale for Depression of 13 (sd = 5.9) over the year. These data suggest but do not prove that TMS might eventually be used as an adjunctive maintenance treatment for at least some patients with bipolar depression. Much work remains. (C) 2004 Wiley-Liss, Inc.
引用
收藏
页码:98 / 100
页数:3
相关论文
共 6 条
  • [1] A controlled trial of daily left prefrontal cortex TMS for treating depression
    George, MS
    Nahas, Z
    Molloy, M
    Speer, AM
    Oliver, NC
    Li, XB
    Arana, GW
    Risch, SC
    Ballenger, JC
    [J]. BIOLOGICAL PSYCHIATRY, 2000, 48 (10) : 962 - 970
  • [2] Transcranial magnetic stimulation -: Applications in neuropsychiatry
    George, MS
    Lisanby, SH
    Sackeim, HA
    [J]. ARCHIVES OF GENERAL PSYCHIATRY, 1999, 56 (04) : 300 - 311
  • [3] A RATING SCALE FOR DEPRESSION
    HAMILTON, M
    [J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1960, 23 (01) : 56 - 62
  • [4] Kozel FA, 2004, CNS SPECTRUMS, V9, P476
  • [5] Left prefrontal transcranial magnetic stimulation (TMS) treatment of depression in bipolar affective disorder: a pilot study of acute safety and efficacy
    Nahas, Z
    Kozel, FA
    Li, XB
    Anderson, B
    George, MS
    [J]. BIPOLAR DISORDERS, 2003, 5 (01) : 40 - 47
  • [6] RATING-SCALE FOR MANIA - RELIABILITY, VALIDITY AND SENSITIVITY
    YOUNG, RC
    BIGGS, JT
    ZIEGLER, VE
    MEYER, DA
    [J]. BRITISH JOURNAL OF PSYCHIATRY, 1978, 133 (NOV) : 429 - 435