Transmuting alpha helices and beta sheets

被引:40
作者
Dalal, S
Balasubramanian, S
Regan, L
机构
[1] YALE UNIV, DEPT BIOCHEM & MOL BIOPHYS, NEW HAVEN, CT 06520 USA
[2] YALE UNIV, DEPT CHEM, NEW HAVEN, CT 06520 USA
来源
FOLDING & DESIGN | 1997年 / 2卷 / 05期
关键词
D O I
10.1016/S1359-0278(97)00036-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Protein architecture involves two main secondary structural classes: alpha helices and beta sheets. Some natural proteins alter their fold in response to changes in solution conditions or as a consequence of mutation. Here, we discuss recent attempts to induce such conformational changes by design: specifically, the motivation and success of efforts to change one protein fold into a different one in response to the 'Paracelsus Challenge'. The results of such efforts may provide a better understanding of the processes that underlie conformational plasticity in proteins.
引用
收藏
页码:R71 / R79
页数:9
相关论文
共 49 条
[1]   An alpha to beta conformational switch in EF-Tu [J].
Abel, K ;
Yoder, MD ;
Hilgenfeld, R ;
Jurnak, F .
STRUCTURE, 1996, 4 (10) :1153-1159
[2]   KINETIC-ANALYSIS OF FOLDING AND UNFOLDING THE 56-AMINO ACID IGG-BINDING DOMAIN OF STREPTOCOCCAL PROTEIN-G [J].
ALEXANDER, P ;
ORBAN, J ;
BRYAN, P .
BIOCHEMISTRY, 1992, 31 (32) :7243-7248
[3]   ASSOCIATION OF BIOMOLECULAR SYSTEMS VIA PULSED-FIELD GRADIENT NMR SELF-DIFFUSION MEASUREMENTS [J].
ALTIERI, AS ;
HINTON, DP ;
BYRD, RA .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (28) :7566-7567
[4]   STRUCTURE OF THE CO1E1 ROP PROTEIN AT 1.7 A RESOLUTION [J].
BANNER, DW ;
KOKKINIDIS, M ;
TSERNOGLOU, D .
JOURNAL OF MOLECULAR BIOLOGY, 1987, 196 (03) :657-675
[5]   DECIPHERING THE MESSAGE IN PROTEIN SEQUENCES - TOLERANCE TO AMINO-ACID SUBSTITUTIONS [J].
BOWIE, JU ;
REIDHAAROLSON, JF ;
LIM, WA ;
SAUER, RT .
SCIENCE, 1990, 247 (4948) :1306-1310
[6]   RIBBONS 2 0 [J].
CARSON, M .
JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1991, 24 :958-&
[7]   Conformational switching in designed peptides: The helix/sheet transition [J].
Cerpa, R ;
Cohen, FE ;
Kuntz, ID .
FOLDING & DESIGN, 1996, 1 (02) :91-101
[8]   STABILITY OF ALPHA-HELICES [J].
CHAKRABARTTY, A ;
BALDWIN, RL .
ADVANCES IN PROTEIN CHEMISTRY, VOL 46, 1995, 46 :141-176
[9]  
CHAN HS, 1991, ANNU REV BIOPHYS BIO, V20, P447, DOI 10.1146/annurev.bb.20.060191.002311
[10]  
Chou P Y, 1978, Adv Enzymol Relat Areas Mol Biol, V47, P45