Catalytic asymmetric homo-aldol reaction of pyruvate - a chiral Lewis acid catalyst that mimics aldolase enzymes

被引：78

作者：

Juhl, K ^{[1
]}

Gathergood, N ^{[1
]}

Jorgensen, KA ^{[1
]}

机构：

[1] Aarhus Univ, Dept Chem, Ctr Met Catalysed React, DK-8000 Aarhus C, Denmark

来源：

CHEMICAL COMMUNICATIONS | 2000年 / 22期

关键词：

D O I：

10.1039/b007125k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first catalytic asymmetric homo-aldol reaction of ethyl pyruvate leading to diethyl-2-hydroxy-2-methyl-4-oxoglutarate in up to 96% enantiomeric excess is reported; this reaction has been investigated for various catalysts, amines and solvents, and it is demonstrated that this new reaction leads to a simple synthetic procedure for the formation of optically active isotetronic acid derivatives.

引用

页码：2211 / 2212

页数：2

共 43 条

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