An angiotensin II receptor antagonist suppresses running-enhanced hippocampal neurogenesis in rat

被引：19

作者：

Mukuda, Takao ^{[1
]}

Sugiyama, Hiroyuki ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Sci, Dept Biol, Higashi Ku, Fukuoka 8128581, Japan

来源：

NEUROSCIENCE RESEARCH | 2007年 / 58卷 / 02期

关键词：

angiotensin II; neurogenesis; hippocampus; losartan; bromodcoxyuridine; neural stem cell;

D O I：

10.1016/j.neures.2007.02.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Hippocampal neurogenesis is enhanced by voluntary running exercise in adult mammals. To elucidate the factors involved in this enhancement, we examined the effects of losartan, an antagonist of angiotensin II type 1 receptors, on the running-enhanced neurogenesis in the adult rat hippocampus. When losartan was administered orally via the drinking water, the running-enhanced cell proliferation in the subgranular zone was almost completely suppressed, indicating that this enhancement may be mediated by angiotensin It and its receptors. (c) 2007 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

引用

页码：140 / 144

页数：5

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