Immunochemical evidence for increased formation of advanced glycation end products and inhibition by aminoguanidine in diabetic rat lenses

被引：35

作者：

Matsumoto, K

Ikeda, K

Horiuchi, S

Zhao, H

Abraham, EC ^{[1
]}

机构：

[1] Kumamoto Univ, Sch Med, Dept Biochem, Kumamoto 860, Japan

[2] Med Coll Georgia, Dept Biochem & Mol Biol, Augusta, GA 30912 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 241卷 / 02期

关键词：

D O I：

10.1006/bbrc.1997.7744

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Water-soluble and urea-soluble protein fractions from control and streptozotocin-diabetic rats were analyzed for AGE's with a CML-specific monoclonal anti-AGE antibody and a polyclonal anti-AGE antibody. AGEs, CML in particular, were significantly increased in the diabetic rats whereas aminoguandine treatment resulted in significant decrease in AGEs. The data also confirm that CML, a glycoxidation product, is a major epitope of AGE structures in lenses. (C) 1997 Academic Press.

引用

页码：352 / 354

页数：3

共 14 条

[1]

AHMED MU, 1986, J BIOL CHEM, V261, P4889

[2]

ARAKI N, 1992, J BIOL CHEM, V267, P10211

[3] AMINOGUANIDINE PREVENTS DIABETES-INDUCED ARTERIAL-WALL PROTEIN CROSS-LINKING [J].