Metabolism and the leukemic stem cell

被引：65

作者：

Abdel-Wahab, Omar ^{[1
]}

Levine, Ross L. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, Leukemia Serv, Dept Med, New York, NY 10065 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2010年 / 207卷 / 04期

关键词：

NADP(+)-DEPENDENT ISOCITRATE DEHYDROGENASE; ACUTE MYELOGENOUS LEUKEMIA; OXIDATIVE STRESS; MUTATIONS; IDH1; HEMATOPOIESIS; ACTIVATION; ALPHA;

D O I：

10.1084/jem.20100523

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Acute leukemias are clonal disorders of hematopoiesis wherein a leukemic stem cell (LSC) acquires mutations that confer the capacity for unlimited self-renewal, impaired hematopoietic differentiation, and enhanced proliferation to the leukemic clone. Many recent advances in understanding the biology of leukemia have come from studies defining specific genetic and epigenetic abnormalities in leukemic cells. Three recent articles, however, further our understanding of leukemia biology by elucidating specific abnormalities in metabolic pathways in leukemic hematopoiesis. These studies potentially converge on the concept that modulation of reactive oxygen species (ROS) abundance may influence the pathogenesis and treatment of acute myeloid leukemia (AML).

引用

页码：677 / 680

页数：4

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